5-Amino-1MQ | Research Compounds USA | 99%+ Purity

5-Amino-1MQ (5-amino-1-methylquinolinium) is a selective, membrane-permeable small-molecule inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase), studied for its role in NAD+ pathway regulation, metabolic energy balance, and fat cell biology — making it one of the most talked-about metabolic research compounds available in the USA today.

Researchers, labs, and institutions across the United States can source verified, research-grade 5-Amino-1MQ with fast dispatch, full documentation, and third-party verified purity.

✅ ≥99% Purity — HPLC & Mass Spectrometry Verified
✅ Batch-Specific Certificate of Analysis (CoA) Included
✅ Third-Party Tested | GMP Manufactured
✅ Fast Dispatch to USA — Tracked Shipping Available

What Is 5-Amino-1MQ?

5-Amino-1MQ — full name 5-amino-1-methylquinolinium — is a synthetic small-molecule quinolinium compound developed as a selective inhibitor of NNMT (nicotinamide N-methyltransferase), an enzyme that plays a central role in nicotinamide methylation, NAD+ availability, and cellular energy regulation.

NNMT is expressed across multiple tissues including adipose (fat), liver, skeletal muscle, brain, heart, and lung. When NNMT activity is elevated, it consumes nicotinamide and depletes the methyl donor SAM (S-adenosylmethionine) — reducing cellular NAD+ levels and impairing mitochondrial energy efficiency. By selectively inhibiting NNMT, 5-Amino-1MQ is studied for its ability to restore NAD+ availability and shift cellular metabolism toward greater energy expenditure.

Two properties make 5-Amino-1MQ particularly useful as a research tool: it is both highly selective for NNMT (without inhibiting structurally similar methyltransferases) and membrane-permeable — meaning it can pass through cell walls to reach its intracellular target directly. This combination of selectivity and permeability has established it as one of the primary research compounds for studying NNMT-dependent metabolic pathways in the USA.

5-Amino-1MQ is a research compound only and is not approved for human therapeutic use.

What Does 5-Amino-1MQ Do?

In research settings, 5-Amino-1MQ has been studied as a molecular probe for exploring NNMT-dependent pathways across metabolic, muscle, and cellular biology contexts. Studies have explored its potential influence on:

• NAD+ availability — by inhibiting NNMT’s consumption of nicotinamide, cellular NAD+ levels are preserved and potentially elevated, supporting mitochondrial energy production
• Metabolic energy expenditure — studies have examined resting energy expenditure changes in animal models without alterations to food intake or physical activity
• Adipocyte and fat cell biology — how NNMT inhibition affects lipid accumulation, fat cell size, and adipose tissue signaling
• SAM and methyl donor balance — the methionine cycle and epigenetic methylation pathways that depend on SAM availability
• Skeletal muscle biology — muscle strength, endurance, stem cell signaling, and age-related muscle function research
• Sirtuin and SIRT1 signaling — downstream NAD+-dependent enzyme activity linked to metabolic and longevity-related gene expression
• Insulin sensitivity and glucose regulation — GLUT4-associated glucose uptake pathways and insulin resistance models
• Cancer metabolic research — NNMT’s role in epigenetic remodeling and cancer-associated metabolic phenotypes

5-Amino-1MQ is a research compound only and is not approved for human therapeutic use.

What Do Studies Say About 5-Amino-1MQ?

Published pre-clinical research on 5-Amino-1MQ spans metabolic biology, obesity research, and — most recently — muscle physiology, with findings appearing in Nature Medicine, Scientific Reports, and PMC-indexed peer-reviewed literature.

Adipose Tissue and Obesity Research
The foundational study on 5-Amino-1MQ, published in Nature Medicine by Kraus et al., examined NNMT inhibition in white adipose tissue of diet-induced obese mice. Treated animals showed substantial reductions in fat mass and fat cell size compared to controls, alongside increased energy expenditure — without any change in food intake or physical activity. Fat cell size in treated models was found to decrease by 30–40%, with significant reductions in visceral adipose accumulation. These findings positioned NNMT as a promising target in metabolic syndrome and obesity research.

NAD+ Pathway and Metabolic Flux Research
PMC-indexed studies have examined 5-Amino-1MQ’s effects on intracellular NAD+, SAM, and nicotinic acid levels in differentiated adipocytes. Findings showed measurable shifts in metabolite pools consistent with NNMT inhibition at concentrations from 0.3–60 µM — supporting its use as a tool compound for studying NAD+ salvage pathway dynamics and methyl donor balance in metabolic models.

Skeletal Muscle Strength and Aging Research
A 2024 study from the University of Texas Medical Branch (published in Scientific Reports) examined 5-Amino-1MQ in aged female mice undergoing exercise training. Treated animals showed greater improvements in grip strength and muscle endurance than exercise alone, with researchers proposing the mechanism involves elevated NAD+ levels from NNMT inhibition supporting mitochondrial function in aging muscle tissue. This has opened a new area of research into NNMT inhibitors as tools for studying age-related muscle decline and sarcopenia.

Insulin Sensitivity and Type 2 Diabetes Research
A PMC review on NNMT’s roles in obesity and type 2 diabetes highlights that NNMT inhibition in pre-clinical models is consistently associated with improved insulin sensitivity, normalized glucose tolerance, and reduced fasting blood glucose. The review concludes that NNMT represents a validated target in metabolic research, with 5-Amino-1MQ among the most studied small-molecule inhibitors in this context. No human clinical trials have yet been published.

Epigenetic and Cancer Biology Research
Research published in Nature Chemical Biology examined NNMT’s role in promoting epigenetic remodeling in cancer cells by creating a metabolic methylation sink — reducing available SAM for DNA and histone methylation. 5-Amino-1MQ is used as a tool compound in studies examining how NNMT activity intersects with cancer cell epigenetics and proliferation, representing a distinct but active area of USA-based research.

Selectivity and Membrane Permeability Data
Published PAMPA and Caco-2 assay data confirm that 5-Amino-1MQ has high passive membrane permeability and does not inhibit structurally similar methyltransferases including DNMT1 and PRMT3 at research concentrations — confirming its suitability as a selective NNMT probe in mechanistic studies.

All referenced findings are from pre-clinical or early-stage research. 5-Amino-1MQ is not approved for human therapeutic use.

Why Buy 5-Amino-1MQ in the USA From Us?

When you buy 5-Amino-1MQ in the USA through our platform, every order includes:

• Batch-specific Certificate of Analysis (CoA)
• HPLC Chromatogram
• Mass Spectrometry Confirmation
• Sterility & Endotoxin Testing Report
• Handling and Solubility Protocol
• Technical Research Support

We supply USA research compounds to licensed researchers, universities, and institutions — with packaging designed to maintain compound integrity throughout transit.

5-Amino-1MQ Product Specifications

How Do I Prepare a 5-Amino-1MQ Working Solution?

5-Amino-1MQ is soluble in DMSO and sterile water. For cell culture work, prepare a stock solution in DMSO and dilute in aqueous media to a final DMSO concentration below 0.1%. Allow the vial to reach room temperature before opening. Dissolve slowly with gentle swirling — do not apply heat. Store stock solutions at -20°C protected from light and avoid repeated freeze-thaw cycles.

5-Amino-1MQ vs Other Metabolic Research Compounds

Frequently Asked Questions — 5-Amino-1MQ USA

Can I buy 5-Amino-1MQ in the USA?
Yes. We supply research-grade 5-Amino-1MQ with fast tracked dispatch across the United States. All orders include full purity documentation and integrity-maintained packaging for research use.

What does NNMT do and why is inhibiting it relevant to research?
NNMT (nicotinamide N-methyltransferase) is an enzyme that methylates nicotinamide — consuming the methyl donor SAM and depleting cellular NAD+ in the process. Elevated NNMT activity has been associated with reduced metabolic efficiency, increased fat storage, and impaired mitochondrial function in research models. Inhibiting NNMT with compounds like 5-Amino-1MQ is studied as a way to restore NAD+ availability and shift cellular energy balance.

Is 5-Amino-1MQ a peptide?
5-Amino-1MQ is technically a synthetic small molecule — a quinolinium compound — rather than a traditional peptide. However, it is widely studied alongside research peptides in metabolic and longevity research programs due to its overlapping areas of interest and similar research use context.

What is the difference between 5-Amino-1MQ and NMN?
NMN (nicotinamide mononucleotide) works by directly supplementing NAD+ precursors. 5-Amino-1MQ works upstream by inhibiting NNMT — the enzyme that breaks down nicotinamide before it can enter the NAD+ synthesis pathway. Rather than adding more precursor, 5-Amino-1MQ is studied as a way to reduce nicotinamide loss at the enzymatic level. Research has proposed that combining the two approaches may produce complementary effects, though this remains pre-clinical.

What purity level should research-grade 5-Amino-1MQ be?
≥98% is the accepted minimum for research-grade compounds, though ≥99% is preferred for enzyme inhibition kinetics, metabolomics assays, and cell-based metabolic studies. All of our USA research compounds — including 5-Amino-1MQ — are HPLC and mass spectrometry verified to ≥99%.

How quickly is 5-Amino-1MQ delivered in the USA?
Orders are dispatched promptly with tracked shipping. Most USA orders arrive within 3–5 business days.

Where can I find 5-Amino-1MQ for sale in the USA?
We offer 5-Amino-1MQ for sale in the USA exclusively for licensed research use, with full documentation and verified purity included as standard with every order.

Research Disclaimer: 5-Amino-1MQ is supplied exclusively for legitimate scientific research purposes in licensed laboratory environments. This product is not intended for human consumption, self-administration, or therapeutic use of any kind. It must be handled by qualified researchers in accordance with all applicable US federal and state regulations and institutional ethics guidelines. By purchasing, you confirm that this compound will be used solely for approved in-vitro or pre-clinical research.