PRODUCTS SOLD ON PEPTIDESLABUSA.COM ARE FOR RESEARCH PURPOSES ONLY AND ARE NOT FOR HUMAN OR VETERINARY USE.
PRODUCTS SOLD ON PEPTIDESLABUSA.COM ARE FOR RESEARCH PURPOSES ONLY AND ARE NOT FOR HUMAN OR VETERINARY USE.
Price range: $40.50 through $132.50
HGH 191AA USA – Buy Online | In Stock & Ready to Ship
Buy HGH 191AA (Human Growth Hormone) in the USA with fast domestic shipping and guaranteed ≥99% purity — fully verified with COA and HPLC documentation. A trusted choice for USA research teams studying growth hormone activity, cellular regeneration and anabolic signaling pathways, HGH 191AA is available in multiple formats to suit varying project needs. No international delays — just reliable, domestically sourced peptides USA researchers can count on.
For research use only. Not intended for human or veterinary use.
HGH 191AA (Human Growth Hormone, 191 Amino Acids) is the full-length, sequence-identical recombinant form of endogenous human growth hormone, studied extensively across endocrinology, metabolic biology, and cellular research for its broad influence on growth signalling, body composition, metabolism, and tissue development — making it the foundational reference compound for the entire growth hormone research field. Researchers and institutions across the USA can source verified, research-grade HGH 191AA with fast domestic dispatch and full batch documentation included.
✅ ≥99% Purity — HPLC & Mass Spectrometry Verified
✅ Batch-Specific Certificate of Analysis (CoA) Included
✅ Sterile Lyophilised Powder | GMP Manufactured
✅ Fast Dispatch Across the USA | USA Peptides In Stock
HGH 191AA is a 191-amino acid recombinant protein structurally identical to endogenous human growth hormone (somatotropin) as naturally secreted by the anterior pituitary gland. The “191AA” designation refers to the full, authentic 191-amino acid sequence of human GH — distinguishing it from lower-quality 192-amino acid variants, which contain an additional methionine residue that alters the protein’s structure, receptor binding behaviour, and research accuracy.
Produced via recombinant DNA technology, HGH 191AA replicates the precise molecular structure of endogenous GH, including its characteristic disulfide bond configuration. It acts by binding to the growth hormone receptor (GHR) on target cells, triggering a broad cascade of anabolic, metabolic, and growth-promoting signalling events — most notably the stimulation of hepatic IGF-1 production.
HGH 191AA is one of the most widely researched recombinant proteins available to buy in the USA, with applications spanning endocrinology, metabolic research, cell biology, and ageing science across research institutions nationwide.
In controlled pre-clinical and laboratory settings, HGH 191AA has been studied across a wide range of physiological and metabolic research applications:
Growth Hormone Receptor (GHR) Signalling Research HGH 191AA is used to study GH receptor activation and the downstream JAK2-STAT5 signalling pathway — one of the primary intracellular cascades triggered by GHR binding. Researchers use recombinant HGH to examine receptor pharmacology, signal transduction kinetics, and how GHR activation differs across tissue types.
IGF-1 Axis Research One of HGH’s most studied effects is its stimulation of IGF-1 production in the liver. Research has examined how GH receptor activation drives hepatic IGF-1 synthesis, how IGF-1 feeds back to regulate GH secretion, and how the GH/IGF-1 axis coordinates growth and metabolic signalling across tissues.
Metabolic Research Studies have examined HGH 191AA’s influence on key metabolic parameters in pre-clinical models — including glucose metabolism, insulin sensitivity, lipid oxidation, and protein synthesis — reflecting the broad role of the GH/IGF-1 axis in regulating systemic energy balance.
Body Composition Research Pre-clinical studies have examined how GH receptor activation influences body composition parameters including lean mass accretion, adipose tissue distribution, and fat metabolism — areas of significant research interest in the context of metabolic disease and ageing models.
Bone and Connective Tissue Research HGH 191AA has been studied for its influence on bone metabolism, osteoblast activity, and collagen synthesis in pre-clinical models — contributing to research on skeletal growth, bone density regulation, and connective tissue biology.
Ageing and Somatopause Research Research has examined recombinant HGH in models of age-related GH decline, exploring how restoration of GH signalling affects metabolic parameters, body composition, and cellular function in aged animal models — a key area of interest in longevity and ageing science.
Cell Proliferation and Tissue Repair Research GH receptor signalling has been studied in the context of cell proliferation, wound healing models, and tissue repair — examining how GHR activation influences cellular growth responses and regenerative signalling in pre-clinical settings.
Immune Function Research Studies have examined GH’s influence on immune cell function and immune regulation in pre-clinical models, reflecting the broader immunomodulatory role of the GH/IGF-1 axis observed in endocrinology research.
GH Deficiency Models HGH 191AA is used in pre-clinical GH deficiency models to study the physiological consequences of GH absence and the effects of GH replacement on growth, metabolism, and organ function — providing foundational insight into somatotropic axis biology.
All applications are for research purposes only. HGH 191AA as supplied is not intended for human therapeutic use.
HGH 191AA has one of the most extensively documented research profiles of any recombinant protein in endocrinology and metabolic science:
GH Receptor Pharmacology: Research has thoroughly characterised the interaction between recombinant HGH and the growth hormone receptor, documenting the two-site binding mechanism by which one GH molecule sequentially binds two GHR molecules to form the active receptor complex — a foundational insight in GH receptor biology with direct relevance to drug development research.
IGF-1 and Downstream Signalling: Studies have consistently demonstrated that GHR activation by recombinant HGH drives hepatic IGF-1 production, with downstream effects documented across multiple tissue types including muscle, bone, and adipose tissue — establishing HGH 191AA as a reliable tool for studying the full GH/IGF-1 signalling cascade.
Metabolic Effects: Pre-clinical research has documented HGH’s broad metabolic influence, including effects on lipolysis, protein synthesis, and glucose homeostasis in animal models — contributing foundational data to the understanding of how the GH axis regulates systemic energy metabolism.
191AA vs 192AA Structure: Research has confirmed that the authentic 191-amino acid sequence is critical for proper receptor binding and downstream signalling. The additional methionine residue in 192AA variants has been shown to alter immunogenicity and receptor interaction profiles — underscoring the importance of the correct 191AA sequence for accurate research outcomes.
Ageing Research: Studies in aged animal models have examined recombinant GH’s effects on age-related physiological decline, with research documenting changes in body composition, metabolic markers, and cellular function following GH signalling restoration — contributing to the growing field of somatopause and longevity research.
Cell Biology Research: GH receptor signalling studies have produced extensive data on JAK2-STAT5 pathway activation, documenting how GHR stimulation by recombinant HGH drives gene expression changes in target tissues — providing molecular-level insight into growth hormone’s broad physiological influence.
| Feature | HGH 191AA | Sermorelin | CJC-1295 | Ipamorelin |
|---|---|---|---|---|
| Type | Recombinant GH protein | GHRH analogue (1-29) | GHRH analogue (modified) | GH secretagogue (GHSR agonist) |
| Mechanism | Direct GHR activation | Stimulates pituitary GH release | Stimulates pituitary GH release | Stimulates pituitary GH release |
| Acts On | GH receptor directly | GHRH receptor (pituitary) | GHRH receptor (pituitary) | Ghrelin receptor (GHSR) |
| Half-Life | ~20–30 minutes | ~10–20 minutes | ~7 days (DAC) | ~2 hours |
| Best For | Direct GHR signalling studies | Acute pituitary stimulation studies | Sustained GHRH-R activation studies | GHSR pathway / combination research |
| Parameter | Specification |
|---|---|
| Full Name | Human Growth Hormone 191 Amino Acids (HGH 191AA) |
| Sequence Length | 191 Amino Acids |
| Type | Recombinant protein — somatotropin identical sequence |
| Receptor Target | Growth Hormone Receptor (GHR) |
| Purity | ≥99% (HPLC & MS Verified) |
| Form | Sterile Lyophilised Powder |
| Solubility | Sterile water, bacteriostatic water, PBS |
| Storage (Powder) | -20°C, protect from light |
| Storage (Reconstituted) | 2–8°C, use promptly |
| Manufacturing | GMP Manufactured |
Every order includes full batch documentation:
✅ Batch-Specific Certificate of Analysis (CoA)
✅ HPLC Chromatogram
✅ Mass Spectrometry Confirmation
✅ Sterility & Endotoxin Testing Report
✅ Reconstitution Protocol
✅ Technical Research Support
Can I buy research-grade HGH 191AA in the USA? Yes. We supply research-grade HGH 191AA to researchers and institutions across the United States. All orders include full batch documentation and are packaged to maintain protein integrity during transit. This compound is supplied strictly for laboratory research use only.
What does 191AA mean in HGH 191AA? The “191AA” designation refers to the full 191-amino acid sequence of authentic human growth hormone — identical to naturally produced endogenous GH. This distinguishes it from inferior 192-amino acid variants, which contain an extra methionine residue that alters receptor binding behaviour and immunogenicity, making them less suitable for accurate research applications.
What is the difference between HGH 191AA and Sermorelin? HGH 191AA directly activates growth hormone receptors on target cells throughout the body — it is the GH signal itself. Sermorelin works upstream, stimulating the pituitary gland to release its own GH by activating GHRH receptors. In research terms, HGH 191AA is used when direct GHR signalling and downstream effects are the focus, while Sermorelin is used to study the hypothalamic-pituitary axis and endogenous GH secretion dynamics.
What is the difference between HGH 191AA and IGF-1? HGH 191AA acts on growth hormone receptors and triggers IGF-1 production in the liver as a key downstream effect. IGF-1 is the primary mediator of many of GH’s anabolic and growth-promoting effects, acting on its own receptor (IGF-1R). Researchers use HGH 191AA when studying the full GH-to-IGF-1 signalling cascade, and IGF-1 directly when focusing on downstream receptor-level effects independent of GH.
What purity is required for HGH 191AA research? ≥98% is considered research-grade, but ≥99% purity is strongly preferred for GH receptor binding assays, IGF-1 stimulation studies, and signalling pathway research where protein purity directly affects experimental accuracy. All HGH 191AA supplied for USA researchers is independently verified to ≥99%.
How is HGH 191AA reconstituted for lab use? Allow the vial to reach room temperature before opening. Add sterile water or bacteriostatic water slowly down the vial wall and swirl gently — do not shake, as vigorous agitation can denature the protein. Use promptly after reconstitution, or aliquot and store at -80°C to preserve activity across multiple experimental uses. Avoid repeated freeze-thaw cycles.
HGH 191AA (Human Growth Hormone, 191 Amino Acids) is supplied exclusively for legitimate scientific research purposes conducted within licensed laboratory environments. This product is not intended for human consumption, self-administration, or any therapeutic application. It must be handled by qualified researchers in compliance with applicable US federal and state regulations and institutional ethics guidelines. By purchasing, you confirm that this compound will be used solely for approved in-vitro or pre-clinical research purposes.
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